AG Bernd Reif - Solid-State NMR
Our group is interested in the structural characterization of biomolecules using MAS solid-state and solution-state NMR spectroscopy. We focus on membrane proteins and amyloidogenic peptides and proteins. These systems are difficult to access by X-ray crystallography or standard solution-state NMR methods.
The research interests can be divided into three areas: 1) We would like to get more insight into the mechanism that lead to protein aggregation at atomic resolution. 2) We study membrane proteins to understand which conformational changes in a membrane protein are required to actively transport a small organic molecule through a phospholipid bilayer. 3) We investigate large protein complexes that are not amenable by solution-state NMR. 4) We work furthermore on the development of methods in solid-state NMR that allow structure and dynamics. These four major reasearch areas are described in more detail below.